BindingDB logo
myBDB logout

BDBM50156055 2-(Diphenyl-methanesulfinyl)-acetamide::2-(benzhydrylsulfinyl)acetamide::2-[(diphenylmethyl)sulfinyl]acetamide::Ambrisentan::CEP-1538::CHEMBL1373::CRL-40476::MODAFINIL::Provigil

SMILES: NC(=O)CS(=O)C(c1ccccc1)c1ccccc1

InChI Key: InChIKey=YFGHCGITMMYXAQ-UHFFFAOYSA-N

Data: 5 KI  12 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50156055   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoamine transporters; Norepinephrine & dopamine


(Homo sapiens (human))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

PubMed
927n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN35,428 from wild type human DAT expressed in COS7 cell membranes incubated for >90 mins by radioligand binding assay


J Med Chem 59: 10676-10691 (2016)

More data for this
Ligand-Target Pair
Monoamine transporters; Norepinephrine & dopamine


(Homo sapiens (human))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

PubMed
2.00E+3n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse

Curated by ChEMBL


Assay Description
Binding affinity to DAT (unknown origin)


J Med Chem 59: 10676-10691 (2016)

More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
2.52E+3n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse - Intramural Research Program

Curated by ChEMBL


Assay Description
Displacement of [3H]WIN35428 from DAT in Sprague-Dawley rat brain membranes


ACS Med Chem Lett 2: 48-52 (2011)

More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
3.80E+3n/an/an/an/an/an/an/an/a



Acenta Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibition of high affinity uptake by the dopamine transporter from rat synaptosomal nerve endings by using [3H]DA as radioligand


J Med Chem 47: 5821-4 (2004)

More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
Reactome pathway
KEGG

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Acenta Discovery, Inc.

Curated by ChEMBL


Assay Description
Inhibition of high affinity uptake by the norepinephrine transporter from rat synaptosomal nerve endings by using [3H]NE as radioligand


J Med Chem 47: 5821-4 (2004)

More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.70E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of 3H-WIN-35428 from DAT in rat striata after 120 mins


Bioorg Med Chem Lett 22: 3751-3 (2012)

More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.70E+3n/an/an/an/an/an/a



Cephalon (France)

Curated by ChEMBL


Assay Description
Inhibition of rat DAT


Eur J Med Chem 54: 949-51 (2012)

More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



Cephalon (France)

Curated by ChEMBL


Assay Description
Inhibition of rat DAT-mediated dopamine reuptake


Eur J Med Chem 54: 949-51 (2012)

More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
Reactome pathway

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.39E+4n/an/an/an/an/an/a



Cephalon (France)

Curated by ChEMBL


Assay Description
Inhibition of rat NET-mediated norepinephrine reuptake


Eur J Med Chem 54: 949-51 (2012)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Cephalon (France)

Curated by ChEMBL


Assay Description
Inhibition of rat SERT-mediated serotonin reuptake


Eur J Med Chem 54: 949-51 (2012)

More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (human))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.10E+4n/an/an/an/an/an/a



Cephalon (France)

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


Eur J Med Chem 54: 949-51 (2012)

More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (human))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.10E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


Bioorg Med Chem Lett 22: 3751-3 (2012)

More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.70E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat DAT


Bioorg Med Chem Lett 22: 2312-4 (2012)

More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat DAT-mediated dopamine reuptake


Bioorg Med Chem Lett 22: 2312-4 (2012)

More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
Reactome pathway

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.39E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat NET-mediated norepinephrine reuptake


Bioorg Med Chem Lett 22: 2312-4 (2012)

More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (human))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.10E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


Bioorg Med Chem Lett 22: 2312-4 (2012)

More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50156055
PNG
(2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhy...)
Show SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat SERT-mediated serotonin reuptake


Bioorg Med Chem Lett 22: 2312-4 (2012)

More data for this
Ligand-Target Pair