BDBM50160873 CHEMBL3794544::US9765054, Compound 50j

SMILES ONC(=O)[C@@H]1[C@@H]([C@H]1c1ccc(cc1)-c1ncc(Cl)cn1)c1ccccc1

InChI Key InChIKey=JLUNPOGVRYFTEO-KZNAEPCWSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50160873   

TargetHistone deacetylase 4(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM50160873(CHEMBL3794544 | US9765054, Compound 50j)
Affinity DataIC50:  140nMAssay Description:Inhibition of HDAC4 catalytic domain (unknown origin) using Boc-Lys(TFA)-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM50160873(CHEMBL3794544 | US9765054, Compound 50j)
Affinity DataIC50:  140nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM50160873(CHEMBL3794544 | US9765054, Compound 50j)
Affinity DataIC50:  430nMAssay Description:Inhibition of HDAC4 in human Jurkat E6-1 cells using Lys-TFA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed