BDBM50162004 1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-((R)-2-methylamino-2-phenyl-ethyl)-1H-pyrimidine-2,4-dione::CHEMBL179269

SMILES CN[C@@H](Cn1c(=O)c(c(C)n(Cc2c(F)cccc2F)c1=O)-c1cccc(OC)c1)c1ccccc1

InChI Key InChIKey=NUNVFFCNHYEXAC-VWLOTQADSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50162004   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162004(1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-met...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162004(1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-met...)
Affinity DataKi:  65nMAssay Description:Binding affinity for Monkey gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162004(1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-met...)
Affinity DataKi:  7.70E+3nMAssay Description:Binding affinity for Rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162004(1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-met...)
Affinity DataIC50:  34nMAssay Description:Inhibition of Human gonadotropin-releasing hormone receptor stimulated calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed