BDBM50162007 (R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione::3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione::3-[(2R)-amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidin-2,4-dione::CHEMBL179691

SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)c2ccccc2)c1=O

InChI Key InChIKey=CJUWBZDJMYYRDG-QFIPXVFZSA-N

Data  11 KI  77 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 88 hits for monomerid = 50162007   

TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity to human GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity for Human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  0.560nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity towards human gonadotropin-releasing hormone receptor (GNRHR) using GnRH peptide as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity at human GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity for Monkey gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity at monkey GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from monkey GnRH receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity for rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity at rat GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataKi:  6.10E+3nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from rat GnRH receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Human gonadotropin-releasing hormone receptor stimulated calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302NMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N315AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  80nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  5.03E+3nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  11.4nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  2.70nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR K115QMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  4.20E+3nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  5.00E+3nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24TMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  2.70nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from human wild type GnRHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  2.80nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F309LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  262nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290QMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  123nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y284LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H182EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S118AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S186KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S168AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  7.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N27EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N315DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111QMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203PMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y284FMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  24.2nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  5.20E+3nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S118NMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189PMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203QMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  182nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR W291FMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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