BDBM50162075 CHEMBL3794167

SMILES CNc1nc2OCCOCCOc3cccc(Cn4c(n2)c1[nH]c4=O)c3

InChI Key InChIKey=OJHLJXROBUJUPQ-UHFFFAOYSA-N

Data  2 IC50  1 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50162075   

TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50162075(CHEMBL3794167)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
LigandPNGBDBM50162075(CHEMBL3794167)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
LigandPNGBDBM50162075(CHEMBL3794167)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasm...More data for this Ligand-Target Pair
LigandPNGBDBM50162075(CHEMBL3794167)
Affinity DataEC50:  3nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as thermal stabilization preincubated for 30 mins followed by heating at 52 degree C for 3 mins...More data for this Ligand-Target Pair