BDBM50163381 CHEMBL3793002

SMILES Cc1ccc(nc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)N1CCC(F)(F)CC1

InChI Key InChIKey=BRCZKOAZCVSKRY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50163381   

TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163381(CHEMBL3793002)
Affinity DataIC50:  1.16E+3nMAssay Description:Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163381(CHEMBL3793002)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed