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BDBM50166571 2-sulfanilamidopyrimidine::2-sulfanilylaminopyrimidine::4-Amino-N-(pyridin-2-yl) benzenesulfonamide (Sulfapyridine) (13)::4-amino-N-(pyrimidin-2-yl)benzenesulfonamide::4-amino-N-2-pyrimidinylbenzenesulfonamide::CHEMBL439::N(1)-2-pyrimidinylsulfanilamide::N(1)-2-pyrimidylsulfanilamide::SULFADIAZINE::sulfapyrimidine::sulphadiazine

SMILES: Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1

InChI Key: InChIKey=SEEPANYCNGTZFQ-UHFFFAOYSA-N

Data: 4 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50166571   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase


(Homo sapiens (human))
BDBM50166571
PNG
(2-sulfanilamidopyrimidine | 2-sulfanilylaminopyrim...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
PDB
MMDB

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Article
PubMed
n/an/a 2.62E+4n/an/an/an/an/an/a



Ataturk University



Assay Description
Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...


J Enzyme Inhib Med Chem 27: 818-24 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Aurora


(Homo sapiens (human))
BDBM50166571
PNG
(2-sulfanilamidopyrimidine | 2-sulfanilylaminopyrim...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
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PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



Astex Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Inhibition of aurora kinase A


J Med Chem 51: 3661-80 (2008)

More data for this
Ligand-Target Pair
Carbonic anhydrase 6 (CA-VI)


(Homo sapiens (Human))
BDBM50166571
PNG
(2-sulfanilamidopyrimidine | 2-sulfanilylaminopyrim...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 1.16E+4n/an/an/an/an/an/a



Ataturk University



Assay Description
Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...


J Enzyme Inhib Med Chem 27: 818-24 (2012)

More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (human))
BDBM50166571
PNG
(2-sulfanilamidopyrimidine | 2-sulfanilylaminopyrim...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
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GoogleScholar
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Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 341n/an/an/an/an/an/a



Ataturk University



Assay Description
Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...


J Enzyme Inhib Med Chem 27: 818-24 (2012)

More data for this
Ligand-Target Pair