BDBM50167961 CHEMBL3800596

SMILES Cc1nc(ncc1-c1cc(cc2[nH]ncc12)C(F)(F)F)N1CC[C@H](O)C1

InChI Key InChIKey=BNTAEJNPQLMGDJ-NSHDSACASA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50167961   

TargetMicrotubule-associated protein 2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50167961(CHEMBL3800596)
Affinity DataIC50:  6nMAssay Description:Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrotubule-associated protein 2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50167961(CHEMBL3800596)
Affinity DataEC50:  121nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50167961(CHEMBL3800596)
Affinity DataIC50: <5.01E+4nMAssay Description:Inhibition of human CYP1A2 expressed in Escherichia coli DH5-alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed