BDBM50169035 1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1H-pyrimidine-2,4-dione::CHEMBL364136::[2',5'-bis-O-(tert-butyldimethylsilyl)-b-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine::[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1', 2'-oxathiole-2',2'-dioxide)thymine

SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O

InChI Key InChIKey=YMSLYTIPSGCZRM-DSPLJNTKSA-N

Data  6 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50169035   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataIC50: >5.00E+5nMAssay Description:The compound was evaluated for inhibition of HIV-1 mutant GluL38-Lys recombinant reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of FLAG-p66/HIS-p51-mediated HIV1 reverse transcriptase dimerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataEC50:  60nMAssay Description:The compound was evaluated for inhibition of HIV-1 wild types GluL38-Lys recombinant reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataIC50:  3.60E+3nMAssay Description:The compound was evaluated for inhibition of HIV-1 wild types GluL38-Lys recombinant reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataEC50:  50nMAssay Description:Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataEC50:  60nMAssay Description:Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataIC50: >1.69E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptase E138K mutant-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed