BDBM50169051 CHEMBL3805576::US10442808, Example 27::US9815842, Example 27

SMILES CC(C)c1c(NC(=O)Nc2cnc(N3CCCS3(=O)=O)c(c2)C(F)(F)F)cnc2cc(Cl)nn12

InChI Key InChIKey=DLBQBILEQBRONY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50169051   

TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50169051(CHEMBL3805576 | US10442808, Example 27 | US9815842...)
Affinity DataIC50:  0.248nMAssay Description:Inhibition of MALT1 (unknown origin) expressed in human Jurkat Clone K22 29Q_H23 cells assessed as IL2 production preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169051(CHEMBL3805576 | US10442808, Example 27 | US9815842...)
Affinity DataIC50:  0.00600nMAssay Description:The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50169051(CHEMBL3805576 | US10442808, Example 27 | US9815842...)
Affinity DataIC50:  0.00600nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50169051(CHEMBL3805576 | US10442808, Example 27 | US9815842...)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of MALT1 C domain (329 to 824 residues) (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg-Cys(PT14)-NH2 as substrate preincubated for 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed