BDBM50171515 CHEMBL190651::N-[4-(4,5-Dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-2-methoxy-acetamide
SMILES COCC(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1
InChI Key InChIKey=BOTQXVZWXJGWAV-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50171515
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: >250nMAssay Description:Inhibition of HER1 kinase in intact DHER14 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 252nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysateMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 10000-50000 nMMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human PDGFR kinase in intact NIHPDGFR cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of HER2 kinase in intact CSH12 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 1000-10000 nMMore data for this Ligand-Target Pair