BDBM50171515 CHEMBL190651::N-[4-(4,5-Dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-2-methoxy-acetamide

SMILES COCC(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1

InChI Key InChIKey=BOTQXVZWXJGWAV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50171515   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171515(CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...)
Affinity DataIC50: >250nMAssay Description:Inhibition of HER1 kinase in intact DHER14 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171515(CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...)
Affinity DataIC50:  252nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171515(CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 10000-50000 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171515(CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human PDGFR kinase in intact NIHPDGFR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171515(CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...)
Affinity DataIC50: >500nMAssay Description:Inhibition of HER2 kinase in intact CSH12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171515(CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 1000-10000 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed