BDBM50172492 CHEMBL3808884

SMILES COC(=O)c1cc2cc(NCc3cc(NC(=O)c4cc(cc(c4)C(F)(F)F)-n4cnc(C)c4)ccc3C)cnc2[nH]1

InChI Key InChIKey=PGQWALGGBUYLQF-UHFFFAOYSA-N

Data  15 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50172492   

TargetTyrosine-protein kinase ABL1(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  6nMAssay Description:Inhibition of His-tagged full length human recombinant wild type ABL expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataEC50:  1.80nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  15nMAssay Description:Inhibition of GST-tagged human recombinant EGFR (668 to1210 residues) expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  22nMAssay Description:Inhibition of GST-tagged full length human recombinant HCK expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  37nMAssay Description:Inhibition of GST-tagged full length human recombinant LYNA expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  40nMAssay Description:Inhibition of full length His-tagged human recombinant cSRC expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  44nMAssay Description:Inhibition of GST-tagged full length human recombinant YES expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  46nMAssay Description:Inhibition of His-tagged full length human recombinant ABL G250E mutant expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  50nMAssay Description:Inhibition of full length GST-tagged human recombinant PDGFRalpha expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  51nMAssay Description:Inhibition of His-tagged full length human recombinant ABL Y253F mutant expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  62nMAssay Description:Inhibition of GST-tagged full length human recombinant FRK expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  69nMAssay Description:Inhibition of His-tagged full length human recombinant LCK expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  73nMAssay Description:Inhibition of His-tagged full length human recombinant ABL E255K mutant expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  112nMAssay Description:Inhibition of GST-tagged human recombinant EGFR T790M mutant (668 to 1210 residues) expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  131nMAssay Description:Inhibition of His-tagged full length human recombinant FYN expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataEC50:  0.0400nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Oribase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)
Affinity DataIC50:  10nMAssay Description:Inhibition of full length GST-tagged human recombinant BRAF V600E mutant expressed in baculovirus using Fluorescein-MAP2K1 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed