BDBM50173314 CHEMBL3808840::US10023564, Example 16

SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1ccccc1)C(=O)Nc1ccc2[nH]ncc2c1

InChI Key InChIKey=JNVSJVSIHCPPTE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50173314   

TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50173314(CHEMBL3808840 | US10023564, Example 16)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of GRK5 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50173314(CHEMBL3808840 | US10023564, Example 16)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50173314(CHEMBL3808840 | US10023564, Example 16)
Affinity DataIC50:  69nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50173314(CHEMBL3808840 | US10023564, Example 16)
Affinity DataIC50:  69nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM50173314(CHEMBL3808840 | US10023564, Example 16)
Affinity DataIC50:  690nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50173314(CHEMBL3808840 | US10023564, Example 16)
Affinity DataIC50:  4.70E+3nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50173314(CHEMBL3808840 | US10023564, Example 16)
Affinity DataIC50:  7.10E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent