BDBM50173531 1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione::CHEMBL197290::dUTPase inhibitor, 8

SMILES OC1CC(OC1CO[Si](c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O

InChI Key InChIKey=HEOOHGVQTWVRSR-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50173531   

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum)
Instituto De Parastiologia Y Biomedicina "Lopez-Neyra

LigandPNGBDBM50173531(1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...)
Affinity DataKi:  2.80E+3nM ΔG°:  -7.57kcal/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Instituto De Parastiologia Y Biomedicina "Lopez-Neyra

LigandPNGBDBM50173531(1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...)
Affinity DataKi:  9.08E+5nM ΔG°:  -4.15kcal/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP deaminase(Campylobacter jejuni)
Instituto De Parastiologia Y Biomedicina "Lopez-Neyra

LigandPNGBDBM50173531(1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...)
Affinity DataKi:  1.00E+9nM ΔG°:  0kcal/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed