BDBM50175274 CHEMBL3809864::US10189809, Compound I-97

SMILES Nc1ccnc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1

InChI Key InChIKey=NSGAFVFYXLWWOI-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50175274   

TargetKappa-type opioid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175274(CHEMBL3809864 | US10189809, Compound I-97)
Affinity DataIC50:  1.20E+3nMAssay Description:Binding affinity to KOP receptor (unknown origin) at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Ironwood Pharmaceuticals

US Patent
LigandPNGBDBM50175274(CHEMBL3809864 | US10189809, Compound I-97)
Affinity DataEC50: <2.00E+4nMAssay Description:Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175274(CHEMBL3809864 | US10189809, Compound I-97)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at KOP receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed