BDBM50175686 (4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone::CHEMBL200106

SMILES OCCCCc1ccc(s1)-c1ccnc(Nc2ccc(cc2)C(=O)N2CCC(CC2)N2CCCC2)n1

InChI Key InChIKey=RJXLKDFSBJOHBM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50175686   

TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated IkappaBalpha degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed