BDBM50175696 4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)benzoic acid::CHEMBL200946

SMILES OC(=O)c1ccc(Nc2nccc(n2)-c2cc3ccccc3s2)cc1

InChI Key InChIKey=INMHCULNPFRWOZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50175696   

LigandPNGBDBM50175696(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175696(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175696(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of TNF-alpha-stimulated IkappaBalpha degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175696(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175696(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175696(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175696(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)be...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed