BDBM50175751 7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2(1H)-one::CHEMBL199625

SMILES CC(C)(C)N1CCC(CC1)c1cc2n(-c3c(Cl)cccc3Cl)c(=O)ccc2c(n1)-c1ccc(F)cc1F

InChI Key InChIKey=AAVGYEROXZEBTI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50175751   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50175751(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50175751(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50175751(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed