BDBM50177054 9-(1'-cyanomethylamino)-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triaza-fluoren-4-one::CHEMBL426190::[3-(4-Ethyl-phenyl)-4-oxo-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-9-ylamino]-acetonitrile

SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(NCC#N)c23)c1=O

InChI Key InChIKey=MYPJFABQXKXTLU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177054   

TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177054(9-(1'-cyanomethylamino)-3-(4'-ethylphenyl)-3H-5-th...)
Affinity DataIC50:  49nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Biocampus

Curated by ChEMBL
LigandPNGBDBM50177054(9-(1'-cyanomethylamino)-3-(4'-ethylphenyl)-3H-5-th...)
Affinity DataIC50:  43nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177054(9-(1'-cyanomethylamino)-3-(4'-ethylphenyl)-3H-5-th...)
Affinity DataIC50:  2.10E+3nMAssay Description:Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed