BDBM50177715 CHEMBL3815054

SMILES CN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1

InChI Key InChIKey=JRJKATLTRNXYCE-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50177715   

TargetPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50177715(CHEMBL3815054)
Affinity DataIC50:  78nMAssay Description:Inhibition of PHKGI (unknown origin) by kinomescan analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50177715(CHEMBL3815054)
Affinity DataIC50:  142nMAssay Description:Inhibition of CLK4 (unknown origin) by kinomescan analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50177715(CHEMBL3815054)
Affinity DataIC50:  936nMAssay Description:Inhibition of ROCK2 (unknown origin) by kinomescan analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50177715(CHEMBL3815054)
Affinity DataIC50:  4nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50177715(CHEMBL3815054)
Affinity DataIC50:  4nMAssay Description:Competitive inhibition of FLT3 D835Y mutant (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50177715(CHEMBL3815054)
Affinity DataIC50:  2nMAssay Description:Inhibition of FLT3 ITD mutant in human MOLM13 cells assessed as reduction in cell viability a after 3 days by cell titer glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50177715(CHEMBL3815054)
Affinity DataIC50:  11nMAssay Description:Inhibition of FLT3 ITD mutant in human MOLM14 cells assessed as reduction in cell viability after 3 days by cell titer glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50177715(CHEMBL3815054)
Affinity DataIC50:  10nMAssay Description:Competitive inhibition of FLT3 ITD mutant (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50177715(CHEMBL3815054)
Affinity DataIC50:  10nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed