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BDBM50179186 (S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-N-((1-benzyl-1H-benzo[d]imidazol-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::CHEMBL436063

SMILES: Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2n1Cc1ccccc1

InChI Key: InChIKey=BJHRGIVVJRVBQV-DITALETJSA-N

Data: 2 KI  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50179186   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50179186
PNG
((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C36H37N5O3/c1-23-16-28(42)17-24(2)29(23)19-30(37)36(44)41-22-27-13-7-6-12-26(27)18-33(41)35(43)38-20-34-39-31-14-8-9-15-32(31)40(34)21-25-10-4-3-5-11-25/h3-17,30,33,42H,18-22,37H2,1-2H3,(H,38,43)/t30-,33-/m0/s1
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PC cid
PC sid
UniChem

Similars

Article
PubMed
1.02n/an/an/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from rat mu opioid receptor in brain P2 synaptosomes


J Med Chem 48: 8112-4 (2005)


Article DOI: 10.1021/jm058259l
BindingDB Entry DOI: 10.7270/Q24J0DQR
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50179186
PNG
((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C36H37N5O3/c1-23-16-28(42)17-24(2)29(23)19-30(37)36(44)41-22-27-13-7-6-12-26(27)18-33(41)35(43)38-20-34-39-31-14-8-9-15-32(31)40(34)21-25-10-4-3-5-11-25/h3-17,30,33,42H,18-22,37H2,1-2H3,(H,38,43)/t30-,33-/m0/s1
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PC sid
UniChem

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Article
PubMed
0.200n/an/an/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Displacement of [3H]deltorphin II from rat delta opioid receptor in brain P2 synaptosomes


J Med Chem 48: 8112-4 (2005)


Article DOI: 10.1021/jm058259l
BindingDB Entry DOI: 10.7270/Q24J0DQR
More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50179186
PNG
((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl...)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCc1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C36H37N5O3/c1-23-16-28(42)17-24(2)29(23)19-30(37)36(44)41-22-27-13-7-6-12-26(27)18-33(41)35(43)38-20-34-39-31-14-8-9-15-32(31)40(34)21-25-10-4-3-5-11-25/h3-17,30,33,42H,18-22,37H2,1-2H3,(H,38,43)/t30-,33-/m0/s1
UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 245n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Functional bioactivity against mu opioid receptor in guinea-pig ileum


J Med Chem 48: 8112-4 (2005)


Article DOI: 10.1021/jm058259l
BindingDB Entry DOI: 10.7270/Q24J0DQR
More data for this
Ligand-Target Pair