BDBM50180251 1-((S)-2-aminopropyl)-1H-indazol-6-ol::CHEMBL371300

SMILES C[C@H](N)Cn1ncc2ccc(O)cc12

InChI Key InChIKey=WBYHTZYHAFNBKW-ZETCQYMHSA-N

Data  15 KI  1 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50180251   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]DOI from cloned human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi:  8.10nMAssay Description:Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]DOI from cloned human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi:  141nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi:  515nMAssay Description:Inhibitory activity against 5HT4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi:  2.27E+3nMAssay Description:Displacement of [3H]clonidine from cloned human adrenergic alpha2A receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi:  4.70E+3nMAssay Description:Displacement of [3H]clonidine from cloned human adrenergic Alpha-2C receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi:  7.87E+3nMAssay Description:Inhibitory activity against 5HT1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against 5HT5A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against 5HT1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibitory activity against adrenergic alpha-1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibitory activity against adrenergic alpha-1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataEC50:  5.60E+3nMAssay Description:Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(RAT)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataEC50:  2nMAssay Description:Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataEC50:  3.70nMAssay Description:Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataEC50:  1.46E+3nMAssay Description:Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataEC50:  2.60E+3nMAssay Description:Activity at adrenergic alpha2A receptor expressed in human clonic adenocarcinoma HT29 cell by tissue contraction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataEC50:  3.05E+3nMAssay Description:Activity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataEC50:  43nMAssay Description:Activity against 5HT2A mediated intracellular calcium mobilization by FLIPR in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at adrenergic alpha2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50180251(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at adrenergic alpha-2A receptor expressed in human clonic adenocarcinoma HT29 cell by adenylyl cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed