BDBM50181880 4-((R)-4-dimethylamino-1-phenylsulfanylmethylbutylamino)-N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-3-nitrobenzenesulfonamide::CHEMBL380502

SMILES CN(C)CCC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(C)(C)CC1

InChI Key InChIKey=NIOPGFLOQNHRPP-AREMUKBSSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50181880   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181880(4-((R)-4-dimethylamino-1-phenylsulfanylmethylbutyl...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181880(4-((R)-4-dimethylamino-1-phenylsulfanylmethylbutyl...)
Affinity DataKi:  92nMAssay Description:Binding affinity to Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181880(4-((R)-4-dimethylamino-1-phenylsulfanylmethylbutyl...)
Affinity DataKi:  728nMAssay Description:Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181880(4-((R)-4-dimethylamino-1-phenylsulfanylmethylbutyl...)
Affinity DataEC50:  1.41E+4nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181880(4-((R)-4-dimethylamino-1-phenylsulfanylmethylbutyl...)
Affinity DataEC50:  2.00E+3nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed