BDBM50181888 CHEMBL198903::N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide

SMILES CC1(C)CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O

InChI Key InChIKey=NLJIRQSWGBPYHN-HHHXNRCGSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50181888   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181888(CHEMBL198903 | N-[4-(4,4-dimethylpiperidin-1-yl)be...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181888(CHEMBL198903 | N-[4-(4,4-dimethylpiperidin-1-yl)be...)
Affinity DataKi:  55nMAssay Description:Binding affinity to Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181888(CHEMBL198903 | N-[4-(4,4-dimethylpiperidin-1-yl)be...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181888(CHEMBL198903 | N-[4-(4,4-dimethylpiperidin-1-yl)be...)
Affinity DataEC50:  368nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181888(CHEMBL198903 | N-[4-(4,4-dimethylpiperidin-1-yl)be...)
Affinity DataEC50:  7.00E+3nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed