BDBM50182687 CHEMBL203645::N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-2-hexynamide

SMILES CCCC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1

InChI Key InChIKey=ISEHGRGNSOYPTL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50182687   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182687(CHEMBL203645 | N-[4-[(3-chloro-4-fluorophenyl)amin...)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of EGF stimulated human erbB1 autophosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182687(CHEMBL203645 | N-[4-[(3-chloro-4-fluorophenyl)amin...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of erbB2 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182687(CHEMBL203645 | N-[4-[(3-chloro-4-fluorophenyl)amin...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of erbB1 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182687(CHEMBL203645 | N-[4-[(3-chloro-4-fluorophenyl)amin...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182687(CHEMBL203645 | N-[4-[(3-chloro-4-fluorophenyl)amin...)
Affinity DataIC50:  170nMAssay Description:Inhibition of HER stimulated human erbB autophosphorylation in MDA-MB-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed