BDBM50184461 CHEMBL3823030
SMILES C[C@@H](O)C(=O)N1CCC(CC1)n1nc(C)c(Nc2ncc(Cl)c(n2)-c2cnn3ccccc23)c1C
InChI Key InChIKey=PZKWAHCUWGHBLH-MRXNPFEDSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50184461
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells after 6 mins by electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of IGF1-induced human IGF1R autophosphorylation expressed in IGF-1R knock-out mouse fibroblastsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of human ERK2 (2 to 360 residues)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human IGF-1R using fluorescent labeled FL-KKSRGDYMTMQIG-CONH2 as substrate after 1 hr 50 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair