BDBM50184493 CHEMBL203791::N,N-diethyl-3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1H-benzo[d]imidazol-1-yl)propan-1-amine::diethyl-(3-{6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-benzoimidazol-1-yl}-propyl)-amine

SMILES CCN(CC)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1cccc(C)n1

InChI Key InChIKey=FNYQWZISNWTOFA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50184493   

TargetMitogen-activated protein kinase kinase kinase 20(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184493(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MLK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184493(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)
Affinity DataIC50:  122nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184493(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)
Affinity DataIC50:  122nMAssay Description:Inhibition of TGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184493(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)
Affinity DataIC50:  100nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184493(CHEMBL203791 | N,N-diethyl-3-(6-(2-(6-methylpyridi...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed