BDBM50188857 8-[1-(3-fluoro-phenyl)-cyclohexyl]-4-phenyl-2,8-diaza-spiro[4.5]decan-1-one::CHEMBL380244

SMILES Fc1cccc(c1)C1(CCCCC1)N1CCC2(CC1)C(CNC2=O)c1ccccc1

InChI Key InChIKey=CZFHRUYUXGGFNR-UHFFFAOYSA-N

Data  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50188857   

TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188857(8-[1-(3-fluoro-phenyl)-cyclohexyl]-4-phenyl-2,8-di...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of [3H]glycine uptake at GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188857(8-[1-(3-fluoro-phenyl)-cyclohexyl]-4-phenyl-2,8-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]NOP from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188857(8-[1-(3-fluoro-phenyl)-cyclohexyl]-4-phenyl-2,8-di...)
Affinity DataIC50:  8.04E+3nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188857(8-[1-(3-fluoro-phenyl)-cyclohexyl]-4-phenyl-2,8-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]NOP from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188857(8-[1-(3-fluoro-phenyl)-cyclohexyl]-4-phenyl-2,8-di...)
Affinity DataIC50:  8.04E+3nMAssay Description:Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188857(8-[1-(3-fluoro-phenyl)-cyclohexyl]-4-phenyl-2,8-di...)
Affinity DataEC50:  423nMAssay Description:Inhibition of [3H]glycine uptake at GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188857(8-[1-(3-fluoro-phenyl)-cyclohexyl]-4-phenyl-2,8-di...)
Affinity DataEC50:  423nMAssay Description:Inhibition of [3H]glycine uptake at GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed