BDBM50189403 CHEMBL3828191
SMILES COc1ccccc1C(=O)Nc1cc2n(C)c(=O)n(C)c2cc1N1CCNC[C@H]1C
InChI Key InChIKey=FQWDVNSBYDXPIO-CQSZACIVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50189403
Affinity DataIC50: 7.90nMAssay Description:Inhibition of synthetic fluorescent ligand binding to recombinant truncated 6H-Flag-TEV-BRPF1 (622 to 738 residues) (unknown origin) expressed in Esc...More data for this Ligand-Target Pair
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of synthetic fluorescent ligand binding to recombinant truncated 6HisFlag-Tev-BRPF2 (551 to 673 residues) (unknown origin) expressed in Es...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of full length BRPF1 in human HUT78 cell nuclear/chromatin extract after 45 mins by chemoproteomic competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.316nMAssay Description:Inhibition of human BRPF1 by BROMOscan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Binding affinity to NanoLuc-tagged BRPF1 isoform 1 bromodomain (625 to 735 residues) (unknown origin) expressed in HEK293 cells co-transfected with h...More data for this Ligand-Target Pair
TargetBromodomain and PHD finger-containing protein 3(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of synthetic fluorescent ligand binding to recombinant truncated 6HisFlag-Tev-BRPF3 (579 to 706 residues) (unknown origin) expressed in Es...More data for this Ligand-Target Pair