BDBM50189415 CHEMBL3828637
SMILES CNC(=O)c1ccc2cncc(-c3ccc4N(C)S(=O)(=O)Cc4c3)c2n1
InChI Key InChIKey=DFYVDBLGPYTIAT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50189415
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...More data for this Ligand-Target Pair
TargetCyclin-C(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin) measured after 1 hr by plate reader assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
The Institute Of Cancer Research
Curated by ChEMBL
The Institute Of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-C(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Chinese Academy Of Medical Sciences And Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...More data for this Ligand-Target Pair