BDBM50189603 CHEMBL377734::N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide

SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1

InChI Key InChIKey=CUPLTRAPYIXFAX-UHFFFAOYSA-N

Data  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50189603   

TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of GSK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50:  40nMAssay Description:Inhibition of FLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha/beta/delta/gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CaMK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50:  400nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Her1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C zeta type(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PKCzetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Her2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50:  200nMAssay Description:Inhibition of PDGFR betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50:  370nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MAPKAPK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50:  40nMAssay Description:Inhibition of FLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSRSF protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SRPK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PKCetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed