BDBM50189986 CHEMBL3827273::US10618914, Compound 25::US11111253, Compound 25

SMILES CC(C)C1Sc2nnc(-c3[nH]nc4CCCc34)n2N=C1c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=TYTNAFBMEWHFMM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50189986   

TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189986(CHEMBL3827273 | US10618914, Compound 25 | US111112...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of IL6-induced STAT3 in human CAL33 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 1-alpha/beta(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189986(CHEMBL3827273 | US10618914, Compound 25 | US111112...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of IFNgamma-induced STAT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189986(CHEMBL3827273 | US10618914, Compound 25 | US111112...)
Affinity DataIC50:  4.40E+3nMAssay Description:Compound samples (in 3-5 mg quantities) were evaluated in a variety of assays. All compound submissions were fully characterized (1H, 13C, IR, HRMS),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 1-alpha/beta(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189986(CHEMBL3827273 | US10618914, Compound 25 | US111112...)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound samples (in 3-5 mg quantities) were evaluated in a variety of assays. All compound submissions were fully characterized (1H, 13C, IR, FIRMS)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189986(CHEMBL3827273 | US10618914, Compound 25 | US111112...)
Affinity DataIC50:  4.40E+3nMAssay Description:Compound samples (in 3-5 mg quantities) were evaluated in a variety of assays. All compound submissions were fully characterized (1H, 13C, IR, FIRMS)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189986(CHEMBL3827273 | US10618914, Compound 25 | US111112...)
Affinity DataIC50:  4.40E+3nMAssay Description:Compound samples (in 3-5 mg quantities) were evaluated in a variety of assays. All compound submissions were fully characterized (1H, 13C, IR, FIRMS)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 1-alpha/beta(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189986(CHEMBL3827273 | US10618914, Compound 25 | US111112...)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound samples (in 3-5 mg quantities) were evaluated in a variety of assays. All compound submissions were fully characterized (1H, 13C, IR, HRMS),...More data for this Ligand-Target Pair
In DepthDetails US Patent