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BDBM50191842 5-(3-chlorophenyl)-4-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)pyrimidine::CHEMBL384466

SMILES: Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1cccc(Cl)c1

InChI Key: InChIKey=TXEVILRPVNDVRU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50191842   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50191842
PNG
(5-(3-chlorophenyl)-4-(4-(4-methyl-1H-imidazol-5-yl...)
Show SMILES Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1cccc(Cl)c1
Show InChI InChI=1S/C19H20ClN5/c1-13-18(23-12-22-13)14-5-7-25(8-6-14)19-17(10-21-11-24-19)15-3-2-4-16(20)9-15/h2-4,9-12,14H,5-8H2,1H3,(H,22,23)
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Similars

Article
PubMed
n/an/a 61n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human NHE1 expressed in Ap1 cell line


Bioorg Med Chem Lett 16: 4796-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.077
BindingDB Entry DOI: 10.7270/Q2DN44P1
More data for this
Ligand-Target Pair