BDBM50192229 3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide::3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide(Clothiazide)::3-Bicyclo[2.2.1]hept-5-en-2-yl-7-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[1,2,4]thiadiazine-6-sulfonic acid amide::6-chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide::CHEMBL61593::CYCLOTHIAZIDE
SMILES: NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C2CC3CC2C=C3)cc1Cl
InChI Key: InChIKey=BOCUKUHCLICSIY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutamate receptor ionotropic AMPA (Homo sapiens (Human)) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assay | Bioorg Med Chem Lett 16: 5057-61 (2006) Article DOI: 10.1016/j.bmcl.2006.07.035 BindingDB Entry DOI: 10.7270/Q24749H7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GRIA2 (Homo sapiens (Human)) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at human GluA2(Q)i expressed in HEK293 cells assessed as enhancement of glutamate-evoked desensitized current by whole cell patch cl... | J Med Chem 59: 448-61 (2016) Article DOI: 10.1021/acs.jmedchem.5b01666 BindingDB Entry DOI: 10.7270/Q2VQ34JK | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GRIA1 (Homo sapiens (Human)) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on 10 uM glutamate-indu... | Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GRIA1 (Homo sapiens (Human)) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on 10 uM glutamate-indu... | Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GRIA1 (Homo sapiens (Human)) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.98E+4 | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Activity at human recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM... | Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic, AMPA 2 (Rattus norvegicus) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | DrugBank PDB Article PubMed | n/a | n/a | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs) Curated by ChEMBL | Assay Description Agonist activity at rat flip iGluR2(Q) expressed in Xenopus laevis oocytes by whole cell patch-clamp method | J Med Chem 51: 6614-8 (2008) Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GRIA2 (Homo sapiens (Human)) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Activity at human recombinant GluA2 receptor flop isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM... | Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic AMPA (Homo sapiens (Human)) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.37E+4 | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Activity at human recombinant GluA3 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM... | Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GRIA1 (Homo sapiens (Human)) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes | Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic AMPA (Homo sapiens (Human)) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a |
NPS Allelix Corporation Curated by ChEMBL | Assay Description Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cells | J Med Chem 43: 4354-8 (2000) Article DOI: 10.1021/jm0002836 BindingDB Entry DOI: 10.7270/Q2R2123P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GRIA2 (Homo sapiens (Human)) | BDBM50192229![]() (3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | n/a | n/a | 2.24E+3 | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Activity at human recombinant GluA2 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM... | Bioorg Med Chem 18: 1381-7 (2010) Article DOI: 10.1016/j.bmc.2009.12.072 BindingDB Entry DOI: 10.7270/Q27W6CB2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |