BDBM50192829 CHEMBL3958704::US10188627, Compound 8a

SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1

InChI Key InChIKey=WZFMWAHUFRLQRH-XDJHFCHBSA-N

Data  1 Kd  18 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50192829   

TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  56nMAssay Description:Transactivation of human Gal4-PPARdelta LBD transfected in African green monkey CV1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Mitobridge

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50: >1.00E+4nMAssay Description:Modulator activity at GAL4-fused human PPARgamma LBD (unknown origin) transfected in African green monkey CV1 cells assessed as receptor transactivat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  5.06nMAssay Description:Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  56nMAssay Description:Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...More data for this Ligand-Target Pair
TargetPPAR delta protein(Rattus norvegicus (Rat))
Mitobridge

US Patent
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  5.06nMAssay Description:Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Mitobridge

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50: >1.00E+4nMAssay Description:Transactivation of yeast GAL4 DNA binding domain-fused PPARgamma LBD (unknown origin) expressed in CV-1 cells after 24 hrs by luciferase reporter gen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataKd:  57nMAssay Description:Binding affinity to His-tagged PPARdelta (unknown origin) by SPR assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  5nMAssay Description:Activation of human PPARdelta LBD expressed in CHO-K1 cells by beta galactosidase enzyme fragment complement based fluorescence assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Mitobridge

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  6.10E+3nMAssay Description:Transactivation of yeast GAL4 DNA binding domain-fused PPARalpha LBD (unknown origin) expressed in CV-1 cells after 24 hrs by luciferase reporter gen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Mitobridge

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of human PPARgamma LBD expressed in CHO-K1 cells by beta galactosidase enzyme fragment complement based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  37nMAssay Description:Transactivation of yeast GAL4 DNA binding domain-fused PPARdelta LBD (unknown origin) expressed in CV-1 cells after 24 hrs by luciferase reporter gen...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Mitobridge

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of human PPARalpha LBD expressed in CHO-K1 cells by beta galactosidase enzyme fragment complement based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  270nMAssay Description:Transactivation of mouse PPARdelta by cell-based luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  37nMAssay Description:Transactivation of GAL4-fused human PPARdelta LBD expressed in African green monkey CV1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Mitobridge

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  6.10E+3nMAssay Description:Transactivation of GAL4-fused human PPARalpha LBD expressed in African green monkey CV1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Mitobridge

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50: >1.00E+4nMAssay Description:Transactivation of GAL4-fused human PPARgamma LBD expressed in African green monkey CV1 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  37nMAssay Description:Modulator activity at GAL4-fused human PPARdelta LBD (128 to residue at C-terminus) transfected in African green monkey CV1 cells assessed as recepto...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Mitobridge

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  6.10E+3nMAssay Description:Modulator activity at GAL4-fused human PPARalpha LBD (unknown origin) transfected in African green monkey CV1 cells assessed as receptor transactivat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50192829(CHEMBL3958704 | US10188627, Compound 8a)
Affinity DataEC50:  5.10nMAssay Description:Transactivation of ProLink tagged human PPARdelta transfected in CHO-K1 cells assessed as interaction with EA labelled SRCP after 3 to 16 hrs by beta...More data for this Ligand-Target Pair