BDBM50193811 CHEMBL3951811

SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3C[C@H](CCCc3c2OC)N2CCN(CCO)CC2)ncc1Cl

InChI Key InChIKey=BCSHRERPHLTPEE-NRFANRHFSA-N

Data  14 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50193811   

TargetInsulin receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of INSR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  22nMAssay Description:Inhibition of NPM-ALK phosphorylation in human SUP-M2 cells after 2 to 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50: >5.60E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone/midazolam as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human ALK expressed in baculovirus using recombinant GST PLC-gamma as substrate assessed as phosphorylation of the substrate after 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  65nMAssay Description:Inhibition of recombinant human INSR expressed in baculovirus using ATP as substrate after 15 mins by TRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50: >5.60E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50: >5.60E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  80nMAssay Description:Inhibition of FAK phosphorylation in human HCC827 cells after 2 to 2.5 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to human ALK (1088 to 1409 residues) expressed in mammalian system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  85nMAssay Description:Inhibition of EML4-ALK tyrosine phosphorylation in human NCI-H3122 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  175nMAssay Description:Inhibition of EML4-ALK tyrosine phosphorylation in human NCI-H2228 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  2nMAssay Description:Inhibition of human FAK expressed in baculovirus after 30 mins using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate by TRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50: >5.60E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50: >5.60E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed