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BDBM50195006 4-(3-chloro-4-fluorophenylamino)-6-((5-methyl-1-(2-morpholinoethyl)-1H-imidazol-4-yl)methylamino)quinoline-3-carbonitrile::CHEMBL219628

InChI string: InChI=1S/C27H27ClFN7O/c1-18-26(33-17-36(18)7-6-35-8-10-37-11-9-35)16-31-20-3-5-25-22(12-20)27(19(14-30)15-32-25)34-21-2-4-24(29)23(28)13-21/h2-5,12-13,15,17,31H,6-11,16H2,1H3,(H,32,34)

SMILES: Cc1c(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)ncn1CCN1CCOCC1

InChI Key: InChIKey=AYWJSJSELYMYNB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50195006   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM50195006
PNG
(4-(3-chloro-4-fluorophenylamino)-6-((5-methyl-1-(2...)
Show SMILES Cc1c(CNc2ccc3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)ncn1CCN1CCOCC1
Show InChI InChI=1S/C27H27ClFN7O/c1-18-26(33-17-36(18)7-6-35-8-10-37-11-9-35)16-31-20-3-5-25-22(12-20)27(19(14-30)15-32-25)34-21-2-4-24(29)23(28)13-21/h2-5,12-13,15,17,31H,6-11,16H2,1H3,(H,32,34)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)

More data for this
Ligand-Target Pair