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BDBM50197688 CHEMBL3952373

SMILES: Nc1c(cnn1-c1ccc2[nH]c(=O)[nH]c2c1)C(=O)c1cc2ccccc2[nH]1

InChI Key: InChIKey=NCPGRDOVYIYSQY-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50197688   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50197688
PNG
(CHEMBL3952373)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(=O)[nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H14N6O2/c20-18-12(17(26)16-7-10-3-1-2-4-13(10)22-16)9-21-25(18)11-5-6-14-15(8-11)24-19(27)23-14/h1-9,22H,20H2,(H2,23,24,27)
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Article
PubMed
n/an/a 3.30E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50197688
PNG
(CHEMBL3952373)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(=O)[nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H14N6O2/c20-18-12(17(26)16-7-10-3-1-2-4-13(10)22-16)9-21-25(18)11-5-6-14-15(8-11)24-19(27)23-14/h1-9,22H,20H2,(H2,23,24,27)
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR4 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50197688
PNG
(CHEMBL3952373)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(=O)[nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H14N6O2/c20-18-12(17(26)16-7-10-3-1-2-4-13(10)22-16)9-21-25(18)11-5-6-14-15(8-11)24-19(27)23-14/h1-9,22H,20H2,(H2,23,24,27)
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50197688
PNG
(CHEMBL3952373)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(=O)[nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H14N6O2/c20-18-12(17(26)16-7-10-3-1-2-4-13(10)22-16)9-21-25(18)11-5-6-14-15(8-11)24-19(27)23-14/h1-9,22H,20H2,(H2,23,24,27)
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Article
PubMed
n/an/a 870n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50197688
PNG
(CHEMBL3952373)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(=O)[nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H14N6O2/c20-18-12(17(26)16-7-10-3-1-2-4-13(10)22-16)9-21-25(18)11-5-6-14-15(8-11)24-19(27)23-14/h1-9,22H,20H2,(H2,23,24,27)
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Article
PubMed
n/an/a 2.70E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50197688
PNG
(CHEMBL3952373)
Show SMILES Nc1c(cnn1-c1ccc2[nH]c(=O)[nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H14N6O2/c20-18-12(17(26)16-7-10-3-1-2-4-13(10)22-16)9-21-25(18)11-5-6-14-15(8-11)24-19(27)23-14/h1-9,22H,20H2,(H2,23,24,27)
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PC sid
UniChem

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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay


J Med Chem 59: 10586-10600 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01156
BindingDB Entry DOI: 10.7270/Q2ZS2ZGV
More data for this
Ligand-Target Pair