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BDBM50199242 6-(4-cyano)-3-[2-(4-morpholinylmethyl)-6-quinolinyl]thieno-[3,2-d]pyrimidin-4(3H)-one::CHEMBL218031

SMILES: O=c1n(cnc2cc(sc12)-c1ccc(cc1)C#N)-c1ccc2nc(CN3CCOCC3)ccc2c1

InChI Key: InChIKey=USYINAXJRSQZMB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50199242   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50199242
PNG
(6-(4-cyano)-3-[2-(4-morpholinylmethyl)-6-quinoliny...)
Show SMILES O=c1n(cnc2cc(sc12)-c1ccc(cc1)C#N)-c1ccc2nc(CN3CCOCC3)ccc2c1
Show InChI InChI=1S/C27H21N5O2S/c28-15-18-1-3-19(4-2-18)25-14-24-26(35-25)27(33)32(17-29-24)22-7-8-23-20(13-22)5-6-21(30-23)16-31-9-11-34-12-10-31/h1-8,13-14,17H,9-12,16H2
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PC sid
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Similars

Article
PubMed
n/an/a 478n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7095-107 (2006)


Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8
More data for this
Ligand-Target Pair