BDBM50199713 CHEMBL3965237::US10913711, Compound 7b::US11555013, Compound 7b::US9862679, Compound 7b

SMILES Fc1ccc(cc1)C(SCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1

InChI Key InChIKey=GUSNPPPWMXNVKP-UHFFFAOYSA-N

Data  15 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50199713   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  4.5nMAssay Description:Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs) were removed, striatum dissected and quickly frozen. Membranes were prepared b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  4.5nMAssay Description:Dopamine Transporter Binding Assay. Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs) were removed, striatum dissected and quick...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  4.5nMAssay Description:Dopamine Transporter Binding Assay. Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs) were removed, striatum dissected and quick...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  28.5nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  28.5nMAssay Description:The uptake assays were carried out 2 days after transfection. Prior to the experiment, the cells were washed once in 500 ul of uptake buffer (25 mM 4...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(RAT)
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  59.5nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(RAT)
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  59.5nMAssay Description:The uptake assays were carried out 2 days after transfection. Prior to the experiment, the cells were washed once in 500 ul of uptake buffer (25 mM 4...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  285nMAssay Description:Serotonin Transporter Binding Assay. Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs, Germantown, N.Y.) were removed, midbrain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  285nMAssay Description:Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs, Germantown, N.Y.) were removed, midbrain dissected and rapidly frozen. Membran...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  285nMAssay Description:Serotonin Transporter Binding Assay. Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs, Germantown, N.Y.) were removed, midbrain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  285nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain stem membranes incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  1.89E+3nMAssay Description:Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs, Germantown, N.Y.) were removed, frontal cortex dissected and rapidly frozen. M...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransporter(Rattus norvegicus (rat))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  1.89E+3nMAssay Description:Norepinephrine Transporter Binding Assay. Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs, Germantown, N.Y.) were removed, fron...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuroepithelial cell-transforming 1(Rat)
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

US Patent
LigandPNGBDBM50199713(CHEMBL3965237 | US10913711, Compound 7b | US115550...)
Affinity DataKi:  1.89E+3nMAssay Description:Norepinephrine Transporter Binding Assay. Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs, Germantown, N.Y.) were removed, fron...More data for this Ligand-Target Pair
In DepthDetails US Patent