BDBM50200389 CHEMBL3936675::US9763922, Example 195

SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2Cc1ccccn1

InChI Key InChIKey=RAIPQLGDNRXVJX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50200389   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200389(CHEMBL3936675 | US9763922, Example 195)
Affinity DataIC50:  7.30E+3nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50200389(CHEMBL3936675 | US9763922, Example 195)
Affinity DataIC50:  280nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200389(CHEMBL3936675 | US9763922, Example 195)
Affinity DataIC50:  90nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed