BDBM50204392 (3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methyl)benzamido)-tetrahydro-2H-pyran-3-carboxamide::CHEMBL234034

SMILES Cc1cc(Cc2ccc(cc2)C(=O)N[C@@H]2CCOC[C@@H]2C(=O)NO)c2ccccc2n1

InChI Key InChIKey=NMHJSIJTDAPUMQ-RBBKRZOGSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50204392   

TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50:  130nMAssay Description:Inhibition of TACE in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of MMP10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-15(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50: >7.00E+3nMAssay Description:Inhibition of MMP15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50204392((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataIC50:  1nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed