BDBM50205849 CHEMBL3938522::US10280165, Example 1

SMILES FC(F)(F)c1cc(Cl)n(Cc2cc(=O)n3c([C@@H]4C[C@H]4C#N)c(Cl)ccc3n2)n1

InChI Key InChIKey=GPMGDUIAVSFGGH-WCBMZHEXSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50205849   

TargetGlutamate receptor 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50205849(CHEMBL3938522 | US10280165, Example 1)
Affinity DataEC50:  4.50E+4nMAssay Description:Positive allosteric modulation of human GluA2 receptor flip isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50205849(CHEMBL3938522 | US10280165, Example 1)
Affinity DataEC50:  9.50E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2D receptor (unknown origin) assessed as increase in glutamate-induced calcium flux measured at time inte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50205849(CHEMBL3938522 | US10280165, Example 1)
Affinity DataEC50:  36.8nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50205849(CHEMBL3938522 | US10280165, Example 1)
Affinity DataEC50:  37nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50205849(CHEMBL3938522 | US10280165, Example 1)
Affinity DataEC50:  4.90E+4nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50205849(CHEMBL3938522 | US10280165, Example 1)
Affinity DataEC50:  4.70E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2C receptor (unknown origin) assessed as increase in glutamate-induced calcium flux measured at time inte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed