BDBM50210282 6-((4-methylpiperazin-1-yl)methyl)-3-(5-(4-phenylbut-1-ynyl)-thiophen-3-yl) -1,4-dihydroindeno[1,2-c]pyrazole::CHEMBL223998

SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCCc3ccccc3)c2)CC1

InChI Key InChIKey=IAUVKJCDBROOOZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50210282   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210282(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(4-phenylb...)
Affinity DataIC50:  542nMAssay Description:Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210282(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(4-phenylb...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of hERG expressed in HEK293 cells assessed as effect on ionic current by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50210282(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(4-phenylb...)
Affinity DataIC50:  48nMAssay Description:Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed