BDBM50212733 CHEMBL425994::N-(2-((dimethylamino)methyl)-4-(3-(piperidin-1-yl)propoxy)phenyl)quinazolin-4-amine

SMILES CN(C)Cc1cc(OCCCN2CCCCC2)ccc1Nc1ncnc2ccccc12

InChI Key InChIKey=XKJWHIKEQTVYTN-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50212733   

TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50212733(CHEMBL425994 | N-(2-((dimethylamino)methyl)-4-(3-(...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50212733(CHEMBL425994 | N-(2-((dimethylamino)methyl)-4-(3-(...)
Affinity DataKi:  9.80nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50212733(CHEMBL425994 | N-(2-((dimethylamino)methyl)-4-(3-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of hERG at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50212733(CHEMBL425994 | N-(2-((dimethylamino)methyl)-4-(3-(...)
Affinity DataEC50:  0.200nMAssay Description:Inverse agonist activity at human histamine H3 receptor by GTP gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed