BDBM50216435 CHEMBL397647::N-(4-(3,4-dichlorobenzamido)benzyl)-N,N-dimethyl-tetrahydro-2H-pyran-4-aminium

SMILES C[N+](C)(Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1)C1CCOCC1

InChI Key InChIKey=BXCVNDLGUWFNBK-UHFFFAOYSA-O

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50216435   

TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216435(CHEMBL397647 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at CCR2 receptor in THP1 cells assessed as inhibition of MCP1-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216435(CHEMBL397647 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of MIP1alpha from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216435(CHEMBL397647 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  20nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50216435(CHEMBL397647 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at CCR2 receptor in PBMC assessed as inhibition of MCP1-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed