BDBM50217569 4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholine::4-[3-(4-Piperidin-1-yl-but-1-ynyl)-benzyl]-morpholine::CHEMBL237087

SMILES C(CN1CCCCC1)C#Cc1cccc(CN2CCOCC2)c1

InChI Key InChIKey=HDRIBIYPLKZUDQ-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50217569   

TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217569(4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholi...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by fluid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217569(4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholi...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217569(4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholi...)
Affinity DataKi:  1.17nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217569(4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholi...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217569(4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholi...)
Affinity DataKi:  7.08nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217569(4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholi...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H1 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217569(4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholi...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H4 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed