BDBM50219382 3-((1s,3s)-3-(4-methylpiperazin-1-yl)cyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine::3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine::CHEMBL249295

SMILES CN1CCN(CC1)[C@H]1C[C@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12

InChI Key InChIKey=PDJARQSWGDDFHH-PSWAGMNNSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50219382   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219382(3-((1s,3s)-3-(4-methylpiperazin-1-yl)cyclobutyl)-1...)
Affinity DataIC50:  58nMAssay Description:Inhibition IGF1R phosphorylation in human MiaPaCa2 cellsMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219382(3-((1s,3s)-3-(4-methylpiperazin-1-yl)cyclobutyl)-1...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219382(3-((1s,3s)-3-(4-methylpiperazin-1-yl)cyclobutyl)-1...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219382(3-((1s,3s)-3-(4-methylpiperazin-1-yl)cyclobutyl)-1...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of ERBb2 phosphorylation in human MIAPaCa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219382(3-((1s,3s)-3-(4-methylpiperazin-1-yl)cyclobutyl)-1...)
Affinity DataIC50:  65nMAssay Description:Inhibition of IGF1R phosphorylation in human MIAPaCa cells by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219382(3-((1s,3s)-3-(4-methylpiperazin-1-yl)cyclobutyl)-1...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of EGFR phosphorylation in human MIAPaCa cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed