BDBM50221526 6-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)quinoline-3-carbonitrile::CHEMBL401644

SMILES COc1ccc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2c1

InChI Key InChIKey=DIVLZGMOXGKIOU-QFBILLFUSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50221526   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221526(6-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)quin...)
Affinity DataKi:  210nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221526(6-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)quin...)
Affinity DataKi:  360nMAssay Description:Inhibition of human recombinant EGFR by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221526(6-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)quin...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of Flt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221526(6-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)quin...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221526(6-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)quin...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221526(6-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)quin...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221526(6-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)quin...)
Affinity DataIC50:  8.27E+3nMAssay Description:Inhibition of human EGFR autophosphorylation in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed