BDBM50221556 4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol::7-(2-chloro-5-hydroxyphenyl)-5-methyl-N-[4-(piperidin-4-ylsulfonyl)phenyl]-1,2,4-benzotriazin-3-amine::CHEMBL250625::US8481536, 536::US8481536, 617

SMILES Cc1cc(cc2nnc(Nc3ccc(cc3)S(=O)(=O)C3CCNCC3)nc12)-c1cc(O)ccc1Cl

InChI Key InChIKey=VAWLAPYBUJTXRS-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50221556   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50221556(4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Targegen

US Patent
LigandPNGBDBM50221556(4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)...)
Affinity DataIC50:  2.80nMAssay Description:Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50221556(4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50221556(4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50221556(4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50221556(4-chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)...)
Affinity DataIC50:  5.20nMT: 2°CAssay Description:Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.More data for this Ligand-Target Pair
In DepthDetails US Patent